Victorian Square contains 750 parking spaces in the city's dining, theatre and casino districts.
The company says sharing real-time parking availability with drivers will allow them to determine in advance whether to drive downtown, ride-share or use other transportation.
Q-Free's ultrasonic directional sensors will monitor space availability which will be displayed on variable message signs in and around the garage.
Americans with Disabilities Act-compliant signs will direct disabled drivers to specific spaces, the company adds.
The system will also allow the city to post parking availability information through an app or website.